Icistech Literature Review: Fatty Acid Therapy Of Butternut Squash Seed Extract (Cucurbita Moschata Duchesnes) On Healing Of Type 2 Diabetes Mellitus Wounds
Keywords:
fatty acids, butternut squash seed, type 2 diabetes mellitus, wound healingAbstract
Background, prevalence of diabetes mellitus (DM) has increased from year to year, the disease has characteristics of increased blood sugar levels, caused by insulin resistance and the inability of the pancreas to secrete insulin. DM can increase the risk of chronic hyperglycemia which results in DM complications in the form of wounds on the feet. Treatment of wound healing due to DM with butternut squash seed (Cucurbita moschata Duchesnes) contains fatty acids including: linoleic, oleic, lauric, and palmitic. The purpose of the review is to determine the effect of butternut squash seed extract (Cucurbita moschata Duchesnes) fatty acid therapy on healing type 2 diabetes mellitus wounds. The review method uses a narrative review method through literature searches, identification, searching, and downloading national and international journal references. Literature studies are conducted through several portals, such as Pubmed, Elseviewer, ScienceDirect, and Google Scholar. The references that have been found are in accordance with the inclusion criteria that have been set. Articles are not used if the topic is not relevant. Reference search in the form of research journals published on the internet in the last 10 years from 2014-2024. Results and discussion, fatty acids in butternut squash seeds have the potential for better wound healing. It is known that fatty acids can change the structure and immunology of the skin because they function as the stratum corneum and can change skin permeability. Fatty acids also inhibit proinflammatory eicosanoids, reactive species (ROS and RNS), and cytokines, thereby affecting inflammation and causing wound healing. Conclusion: therapy with fatty acids in butternut squash seed extract (Cucurbita moschata Duchesnes) can cause healing of type 2 diabetes mellitus wounds.
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